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The Blitz Lab is located in Pearson Hall, home of the Department of Biology at Miami University in Oxford, Ohio. Our research is focused on determining how the nervous system integrates information about the internal and external environment in order to select an appropriate motor output. We are working to identify cellular and synaptic mechanisms of plasticity enabling the flexibility of neural circuits underlying rhythmic behaviors. These questions are being addressed in a model system, the stomatogastric nervous system of the Jonah crab, Cancer borealis. For more information on current projects in the lab, see our Research page.

 

poc mcn1 feedback plasticity

Plasticity of circuit feedback. A, Confocal image of a neurohormonal organ, the ACO, with depth coding applied. B, Circuit neuron AB provides feedback to the identified modulatory circuit input MCN1. C, Control feedback strength from the circuit neuron AB (active during each PD neuron burst) is relatively weak, having little influence on MCN1 activity. D, Peptide release from the ACO strengthens AB feedback resulting in rhythmic interruptions in MCN1 activity. This activity pattern is essential for eliciting a distinct version of chewing output from the circuit. Swallie, Monti and Blitz (2015) PLoS ONE 10: e0142956; Blitz and Nusbaum (2012) J Neurosci 32:9182.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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